WASHINGTON : Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission.

Scientists combined empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences.

They then integrated these results with interaction-based network models of disease transmission and show that superspreading, when it is fat-tailed, leads to pronounced transmission by increasing dispersion.

The findings of the study indicate that large superspreading events should be the targets of interventions that minimize tail exposure.

Superspreading has been recognized as an important phenomenon arising from heterogeneity in individual disease transmission patterns.

The role of superspreading as a significant source of disease transmission has been appreciated in outbreaks of measles, influenza, rubella, smallpox, Ebola, monkeypox, SARS, and SARS-CoV-2.

A basic definition of an nth-percentile superspreading event (SSE) has been proposed to be any infected individual who infects more people than does the nth-percentile of other infected individuals.

Hence, if the number of secondary cases is randomly distributed, then for large n, SSEs can be viewed as right-tail events. A natural language for understanding the tail events of random distributions is extreme value theory, which has been applied to contexts as diverse as insurance and contagious diseases.

The researchers applied extreme value theory to empirical data on superspreading in order to gain insight into this critical phenomenon impacting the current COVID-19 pandemic. (ANI)

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